Drug repositioning, the strategy of finding new applications for known drugs, has been growing in importance in the last few years as an alternative to traditional drug discovery. Repurposed drugs are already well-characterized, which means that existing pharmacological and toxicity data can help speed their path to the clinic. Well-known success stories for this approach include Pfizer’s Viagra, repurposed for erectile dysfunction, and methotrexate, repurposed for rheumatoid arthritis.
At Atlas Regeneration we implement drug repositioning using proprietary algorithms to systematically screen in silico for drugs and other interventions that can enhance the targeted differentiation of pluripotent cells into multiple subtypes. Our unique pipeline couples high-throughput in silico screening with in vivo and in vitro validation, and can be applied to improve clinical treatment strategies as well as stem cell models of disease.